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cyclophosphamide + doxorubicin + ethinyl estradiol + fluorouracil
- Development stage
- Unknown
- Lead developer
- Takeda
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A combination of four drugs including two chemotherapy agents (cyclophosphamide and doxorubicin), a synthetic estrogen (ethinyl estradiol), and an antimetabolite (fluorouracil). Cyclophosphamide is an alkylating agent that prevents cancer cells from dividing by cross-linking DNA strands and decreasing DNA synthesis. Doxorubicin is an anthracycline antibiotic that works by damaging the DNA inside cancer cells. The specific role of ethinyl estradiol in this combination is not clear from the available information. Fluorouracil (5-FU) is an antimetabolite that interferes with DNA and RNA synthesis.
02
Targets
TS (Thymidylate synthase)ESR1 (ERα)TOP2A (DNA topoisomerase II)ESR2 (ERβ)DNA
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