Drug intelligence / Profile preview

cyclophosphamide + doxorubicin + paclitaxel + sunitinib

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Intravenous, Oral
01

Overview

This appears to be a non-standard combination of three chemotherapy agents (cyclophosphamide, doxorubicin, paclitaxel) and one targeted therapy (sunitinib). While cyclophosphamide, doxorubicin, and paclitaxel are commonly used together as AC-T regimen for breast cancer, sunitinib is typically used separately for different indications such as kidney cancer, gastrointestinal stromal tumors, and pancreatic neuroendocrine tumors. There is no established clinical use for this specific four-drug combination in the provided information.

02

Targets

VEGFR2 (Vascular endothelial growth factor receptor 2)TOP2A (DNA topoisomerase II)KIT (c-KIT proto-oncogene receptor tyrosine kinase)DNATUBB (Tubulin (alpha and beta subunits))PDGFRB (Platelet-derived growth factor receptor beta)RET (Rearranged during transfection receptor tyrosine kinase)FLT3 (Fms related receptor tyrosine kinase 3)

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