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Drug intelligence / Profile preview
cyclophosphamide + epirubicin + fluorouracil + methotrexate
- Development stage
- Phase 3
- Lead developer
- Baxter
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A sequential chemotherapy regimen used in the treatment of breast cancer, particularly early-stage and node-positive disease. The regimen typically consists of epirubicin administered first, followed by the standard CMF (cyclophosphamide, methotrexate, and fluorouracil) combination. Clinical trials have shown this sequential approach to be superior to CMF alone for adjuvant treatment of early breast cancer.
- Other names
- epirubicin-CMFE-CMF
02
Targets
DNADHFR (Dihydrofolate reductase)TS (Thymidylate synthase)TOP2A (DNA topoisomerase II)
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