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cyclophosphamide + epirubicin + fluorouracil + methotrexate + vincristine

Development stage: Unknown
Lead developer: Takeda
Modality: Small Molecules
Administration: Intravenous

Overview

A combination chemotherapy regimen containing cyclophosphamide, epirubicin, fluorouracil, methotrexate, and vincristine. This anthracycline-based polychemotherapy has been studied in clinical trials for breast cancer treatment, particularly for node-positive and metastatic disease. The regimen combines an alkylating agent (cyclophosphamide), an anthracycline (epirubicin), an antimetabolite (fluorouracil and methotrexate), and a vinca alkaloid (vincristine).

Targets

TS (Thymidylate synthase)DHFR (Dihydrofolate reductase)TOP2A (DNA topoisomerase II)DNATUBB (Tubulin (alpha and beta subunits))

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