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cyclophosphamide + methotrexate
- Development stage
- Unknown
- Lead developer
- Takeda
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Cyclophosphamide + methotrexate is a chemotherapy combination used in cancer treatment. This low-dose combination therapy works through multiple mechanisms, with cyclophosphamide stopping cancer cells from reproducing and methotrexate inhibiting cells from making and repairing DNA. The combination is often administered in a metronomic (continuous low-dose) fashion, which targets both endothelial cells and mechanisms of angiogenesis. This approach is particularly useful for treating drug-resistant cancers. The combination has shown efficacy in metastatic breast cancer and has been studied with additional agents like celecoxib for enhanced anti-angiogenic effects.
- Other names
- CM
02
Targets
DNADHFR (Dihydrofolate reductase)ATIC (Aminoimidazole carboxamide ribonucleotide transformylase)TS (Thymidylate synthase)
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