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cyclophosphamide + methotrexate + vinorelbine + capecitabine

Development stage: Preclinical
Lead developer: Takeda
Modality: Small Molecules
Administration: Oral, Intravenous

Overview

A combination chemotherapy regimen consisting of cyclophosphamide, methotrexate, vinorelbine, and capecitabine. This combination includes both oral and intravenous agents with different mechanisms of action for treating cancer. Cyclophosphamide is an alkylating agent, methotrexate is an antimetabolite that inhibits dihydrofolate reductase, vinorelbine is a vinca alkaloid that disrupts microtubule assembly, and capecitabine is a prodrug that converts to fluorouracil in tumor cells.

Targets

TUBB (Tubulin (alpha and beta subunits))TS (Thymidylate synthase)DNADHFR (Dihydrofolate reductase)

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