Drug intelligence / Profile preview

cyclosporine + danazol + eltrombopag + methenolone + romiplostim

Development stage
Preclinical
Lead developer
Sandoz
Modality
Small Molecules, Recombinant Proteins and Enzymes
Administration
Oral, Subcutaneous, Intravenous, Intramuscular
01

Overview

This is a **combination of five active pharmaceutical ingredients**: cyclosporine (an immunosuppressant), danazol (a synthetic androgen with immunomodulatory effects), eltrombopag (a thrombopoietin receptor agonist that increases platelet production), methenolone (an androgen/anabolic steroid with erythropoiesis-stimulating properties), and romiplostim (a recombinant fusion protein that mimics thrombopoietin to induce platelet production). While each drug is approved individually for various indications, this specific combination is not known to be an approved formulation or marketed as a fixed-dose combination. Such a regimen may be explored in experimental protocols for rare hematologic disorders such as refractory aplastic anemia or thrombocytopenia, targeting diverse mechanisms: immunosuppression, androgenic stimulation of erythropoiesis, and augmentation of thrombopoiesis[1][2][3][7][8].

02

Targets

AR (Adrenergic receptors)CN (Calcineurin)PPIA (Peptidyl-prolyl cis-trans isomerase A)PR (Progesterone receptor)TPOR (Thrombopoietin receptor)Cyp (Cyclophilin family)

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