cyclosporine + methotrexate

Cyclosporine + methotrexate is a combination of two immunosuppressive agents used primarily for the treatment of severe autoimmune diseases such as rheumatoid arthritis and chronic plaque psoriasis. Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation by inhibiting interleukin-2 production. Methotrexate is an antimetabolite and antifolate agent that inhibits enzymes involved in nucleotide synthesis (notably dihydrofolate reductase), leading to suppression of cell proliferation and inflammation. The combination allows for lower doses of each drug compared to monotherapy while maintaining efficacy and potentially reducing toxicity. This regimen has been shown effective in patients with severe or recalcitrant disease not controlled by single-agent therapy[2][3][4][5].

Brand names

RheumatrexGengrafNeoralSandIMMUNE

Other names

cyclosporine + methotrexate