cyclosporine + mycophenolate mofetil + antilymphocyte serum + corticosteroids

This is a combination immunosuppressive regimen used primarily in organ transplantation to prevent graft rejection. The combination leverages synergistic effects between the components: - **Cyclosporine**: A calcineurin inhibitor that suppresses T-cell activation and proliferation - **Mycophenolate mofetil (MMF)**: A prodrug of mycophenolic acid that inhibits inosine monophosphate dehydrogenase, preventing T and B lymphocyte proliferation - **Antilymphocyte serum**: Contains antibodies that target lymphocytes, causing selective depletion of circulating lymphocytes - **Corticosteroids**: Broad anti-inflammatory and immunosuppressive agents This multi-drug regimen provides comprehensive immunosuppression through different mechanisms, improving efficacy while potentially allowing for lower doses of individual components to reduce toxicity. Clinical studies have shown that the combination of cyclosporine and mycophenolate mofetil has synergistic immunosuppressive effects, particularly in kidney transplantation.

Brand names

NeoralCellCeptThymoglobuline

Other names

cyclosporin + mycophenolate mofetil + antilymphocyte serum + corticoids