cyclosporine + prednisolone

Cyclosporine + prednisolone is a combination of two immunosuppressive agents used primarily for the treatment of immune-mediated diseases, particularly when monotherapy is insufficient or not tolerated. Cyclosporine is a calcineurin inhibitor that suppresses T-cell activation by inhibiting the phosphatase activity of calcineurin, thereby reducing the transcription of interleukin-2 and other cytokines essential for T-cell proliferation and function[5][6][8]. Prednisolone is a synthetic glucocorticoid that binds to the glucocorticoid receptor, modulating gene expression to inhibit pro-inflammatory signals and promote anti-inflammatory effects[10]. The combination has been shown to be effective in conditions such as pemphigus vulgaris, refractory celiac disease, and minimal change nephrotic syndrome where rapid immunosuppression or steroid-sparing effects are desired[1][2][3]. This regimen can induce remission more quickly than corticosteroids alone in some cases and may allow for lower doses of each drug, potentially reducing side effects.

Other names

steroid + cyclosporincyclosporine + prednisolonecyclosporine + steroidsteroid + cyclosporinecyclosporin + steroidcyclosporin + prednisolone