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cyclosporine + trehalose
- Development stage
- Phase 3
- Lead developer
- Huons
- Modality
- Small Molecules
- Administration
- Ophthalmic
01
Overview
A fixed-dose ophthalmic combination of **cyclosporine** (an immunosuppressant calcineurin inhibitor) and **trehalose** (a disaccharide with cytoprotective and autophagy-promoting properties), developed primarily for the treatment of **dry eye disease**. Cyclosporine acts by inhibiting T cell activation and reducing ocular inflammation, while trehalose stabilizes cell membranes, protects epithelial cells from desiccation, and mitigates osmotic stress. The combination aims to provide synergistic therapeutic benefits for moderate to severe dry eye disease by addressing both inflammatory and cellular protection mechanisms. The product is under development by **Huons**, with recent phase II clinical trials completed in patients with dry eye disease[1][4].
- Brand names
- Moisview Eye Drops
- Other names
- ciclosporine/trehalosetrehalose/ciclosporine
02
Targets
MPTP (Mitochondrial permeability transition pore)TFEB (Transcription factor EB)CN (Calcineurin)
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