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Drug intelligence / Profile preview
cyproterone acetate + estradiol
- Development stage
- Unknown
- Lead developer
- Bayer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This drug is a hormonal combination therapy consisting of **cyproterone acetate** (50 mg) and **natural estradiol** (2 mg), currently being studied by **University Hospital, Lille** for the treatment of **polycystic ovary syndrome (PCOS)**. Cyproterone acetate is a synthetic steroidal compound with potent antiandrogenic and progestogenic activity, while estradiol is a naturally occurring estrogen. The combination is designed to suppress the hypothalamic-pituitary-gonadal (HPG) axis, thereby reducing ovarian androgen production and blocking the effects of circulating androgens at the receptor level. In the specific clinical trial (NCT03738423), this regimen is used to investigate microstructural and metabolic changes in the hypothalamus of women with PCOS using high-resolution magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy.
- Other names
- cyproterone acetate and estradiolCPA + E2
02
Targets
AR (Adrenergic receptors)ER (Estrogen receptor)GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)PR (Progesterone receptor)
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