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CYT004-MelQbG10 + montanide + imiquimod
- Development stage
- Unknown
- Lead developer
- Kuros Biosciences
- Modality
- Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Small Molecules, Recombinant Protein Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Subcutaneous, Topical
01
Overview
CYT004-MelQbG10 is a therapeutic virus-like particle (VLP) vaccine developed to target melanoma, specifically in HLA-A2 positive patients with advanced (stage III/IV) malignant melanoma. The active component, CYT004-MelQbG10, consists of a VLP derived from the coat protein of bacteriophage Qβ and loaded with the CpG oligonucleotide "G10," designed to enhance immune activation. The mechanism involves modulation of MAGEA1 (Melanoma-associated antigen 1), aiming to induce an anti-tumor immune response against melanoma cells expressing this antigen[1][5]. Montanide acts as an adjuvant to further stimulate the immune system, while imiquimod is a topical immunomodulator that activates innate immunity via TLR7 signaling. This combination has been evaluated in clinical trials for its safety and immunogenicity in advanced melanoma patients[4][8]. The primary developer is Kuros Biosciences Ltd., with Cytos Biotechnology AG involved historically[1][3].
- Other names
- Melan-A VLP vaccineMelanoma virus-like particle vaccine
02
Targets
MART-1/HLA-A*02:01 (Melanoma-associated antigen (Melanoma antigen recognized by T cells 1, Melanocyte protein PMEL, Tyrosinase) peptide-HLA-A*02:01 complex)TLR9 (Toll-like receptor 9)TLR7 (Toll-like receptor 7)
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