cytidine 5'-monophosphate

HY-W009162 (cytidine 5'-monophosphate) is an endogenous nucleotide metabolite that has been identified as a novel inhibitor of F-box protein 6 (FBXO6). FBXO6 is an E3 ubiquitin ligase component that plays a non-canonical role in driving macrophage activation during sepsis-induced acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). By inhibiting FBXO6, HY-W009162 prevents the K63-linked ubiquitination and degradation of the phosphatase PPM1D, thereby stabilizing PPM1D to dephosphorylate the p65 subunit of NF-kappaB and suppress NF-kappaB-mediated inflammatory signaling. In vivo, HY-W009162 has been shown to significantly attenuate lung leakage, lactate dehydrogenase (LDH) release, pro-inflammatory cytokine production, and overall lung inflammation, highlighting its therapeutic potential for sepsis-induced lung injury.

Other names

5'-CMP5'-cytidylic acidcytidine 5'-(dihydrogen phosphate)cytidine 5'-phosphatecytidine monophosphatecytidylic acid