D-Arg6, AzaGly10-GnRH II

D-Arg6, AzaGly10-GnRH II is a synthetic decapeptide analog of gonadotropin-releasing hormone II (GnRH-II). It functions as a potent agonist that has been studied for its ability to regulate the invasiveness and motility of human endometrial cancer cells. Although it is a GnRH-II analog, research indicates that its biological effects in endometrial cancer cell lines, such as Ishikawa and ECC-1, are primarily mediated through the GnRH-I receptor (GnRHR1). Activation of this receptor by the agonist triggers downstream signaling via mitogen-activated protein kinases (MAPKs), specifically ERK1/2 and JNK, which subsequently leads to the activation of matrix metalloproteinase-2 (MMP-2). This signaling cascade is implicated in promoting tumor cell migration and invasion, suggesting that GnRH-II signaling may play a role in the progression of reproductive cancers. It is primarily utilized as a research tool in preclinical oncology studies.

Other names

GnRH-II agonist[D-Arg6, AzaGly10]GnRH II[D-Arg(6), Aza-Gly(10)]GnRH-II