Drug intelligence / Profile preview

dabigatran + pitavastatin

Development stage
Unknown
Lead developer
Boehringer Ingelheim
Modality
Small Molecules
Administration
Oral
01

Overview

Dabigatran is an oral anticoagulant used to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation. It is also indicated for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE), including after hip replacement surgery. Dabigatran acts as a direct thrombin inhibitor by reversibly binding to the active site of thrombin, thereby preventing the conversion of fibrinogen to fibrin and inhibiting clot formation[1][4][5][6][8]. Pitavastatin is an oral lipid-lowering agent used together with diet, weight loss, and exercise to reduce levels of low-density lipoprotein (LDL) cholesterol and other fatty substances in the blood. It belongs to the statin class (HMG-CoA reductase inhibitors) and works by inhibiting HMG-CoA reductase, a key enzyme involved in cholesterol synthesis[2].

Other names
dabigatran etexilatepitavastatin calcium
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)F2 (Thrombin)

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