Drug intelligence / Profile preview

daclizumab + mycophenolate mofetil + prednisolone

Development stage
Discontinued
Lead developer
Roche
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous, Oral
01

Overview

This is a combination immunosuppressive regimen consisting of daclizumab (a humanized monoclonal antibody targeting CD25 on activated T cells), mycophenolate mofetil (an inosine monophosphate dehydrogenase inhibitor), and prednisolone (a corticosteroid). This combination is primarily used to prevent organ rejection in transplant recipients, particularly in kidney transplantation. The regimen works through multiple mechanisms to suppress the immune response: daclizumab blocks IL-2 receptor signaling, mycophenolate mofetil inhibits lymphocyte proliferation, and prednisolone provides broad anti-inflammatory effects.

02

Targets

GR (Glucocorticoid receptor)IL2RA (Interleukin-2 receptor alpha subunit)IMPDH (Inosine-5'-monophosphate dehydrogenase 1)

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