daily irrigation-University of California, Berkeley

Daily irrigation-University of California, Berkeley refers to a clinical intervention involving the daily application of a sterile, preservative-free, borate-buffered saline solution (specifically Unisol 4) to the ocular surface. Developed and evaluated by researchers at the Clinical Research Center, School of Optometry, University of California, Berkeley, the intervention was designed for use during 30-day continuous wear of silicone hydrogel contact lenses. The procedure involves subjects irrigating their eyes every morning upon awakening and whenever dryness symptoms occur, accompanied by gentle nudging of the lens to promote fluid flow beneath it. The primary objective was to determine if daily irrigation could mitigate increases in corneal epithelial permeability and reduce the risk of adverse events associated with extended contact lens wear. However, a randomized controlled trial published in 2014 concluded that the intervention did not significantly improve ocular surface integrity or decrease the risk of adverse events.

Brand names

Unisol 4Unisol4Unisol-4

Other names

daily saline irrigationdaily morning irrigation