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dalutrafusp alfa + mFOLFOX6

Development stage: Unknown
Lead developer: Gilead Sciences
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous

Overview

Dalutrafusp alfa + mFOLFOX6 is a combination regimen consisting of dalutrafusp alfa, an investigational bifunctional fusion protein targeting CD73 and TGF-beta, and the mFOLFOX6 chemotherapy regimen. mFOLFOX6 includes oxaliplatin, leucovorin (folinic acid), and fluorouracil (5-FU), and is used as a standard chemotherapy backbone for gastrointestinal malignancies such as colorectal cancer. Dalutrafusp alfa is developed to enhance antitumor immune response by blocking the immunosuppressive effects of TGF-beta and adenosine signaling (via CD73), while mFOLFOX6 acts by inhibiting DNA synthesis and repair and interfering with folate metabolism to induce cytotoxicity in rapidly dividing cancer cells.

Other names: dalutrafusp alfa + mFOLFOX6

Targets

TGFB (GARP–latent transforming growth factor beta 1 complex)TS (Thymidylate synthase)NT5E (Cluster of Differentiation 73)DNA

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