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danzhi qing'e
- Development stage
- Phase 2
- Lead developer
- Tianjin University of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Danzhi Qing'e is a Traditional Chinese Medicine (TCM) formula developed by the Tianjin University of Traditional Chinese Medicine for the treatment of menopausal syndrome (perimenopausal syndrome). It is a modified version of the classic 'Qing'e Wan' formula, specifically incorporating *Cortex Moutan* (Danpi) and *Fructus Gardeniae* (Zhizi) to address symptoms associated with 'kidney deficiency and liver fire' in TCM theory. The formula typically consists of *Psoralea corylifolia*, *Eucommia ulmoides*, *Juglans regia*, *Paeonia suffruticosa*, and *Gardenia jasminoides*. Mechanistically, Danzhi Qing'e acts as a phytoestrogen complex that modulates the hypothalamic-pituitary-ovarian (HPO) axis, regulates serum levels of estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH), and interacts with estrogen receptors to alleviate vasomotor symptoms, insomnia, and mood disturbances associated with menopause.
- Brand names
- Danzhi Qing'e
- Other names
- Danzhi Qing'e formulaDanzhi Qing'e decoctionDanzhi Qing'e granulesDZQE
02
Targets
AcetylcholinesteraseAR (Adrenergic receptors)CA2 (Carbonic Anhydrase 2)CA4 (Carbonic anhydrase 4)CYP19A1 (Aromatase)ESR1 (ERα)ESR2 (ERβ)MMP2 (Matrix metalloproteinase-2)MAPK3 (Mitogen-activated protein kinase 1)AKT (RAC-alpha serine/threonine-protein kinase)
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