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dapagliflozin + bisoprolol
- Development stage
- Preclinical
- Lead developer
- Servier
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Dapagliflozin + bisoprolol is a fixed-dose combination therapy being developed by Servier for the treatment of heart failure. The combination targets two complementary pathways: SGLT2 inhibition and beta-adrenergic blockade. Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, reduces glucose reabsorption in the kidney, leading to glycosuria and providing significant cardiovascular benefits, including reduced preload and afterload. Bisoprolol is a selective beta-1 adrenergic receptor blocker that reduces heart rate and myocardial oxygen demand, which is a cornerstone of heart failure management. This combination therapy, associated with Servier's cardiovascular pipeline (which includes the Acertil brand), aims to provide synergistic effects in managing heart failure symptoms and improving patient outcomes through a simplified oral regimen.
- Other names
- dapagliflozin and bisoprololdapagliflozin/bisoprololbisoprolol/dapagliflozin
02
Targets
ADRB2 (β2)ADRB1 (β1)ADRB3 (β3)SGLT2 (Sodium-glucose cotransporter protein subunit 2)SLC5A1 (Sodium Glucose Cotransporter 1)
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