Drug intelligence / Profile preview

dapagliflozin + telmisartan

Development stage
Preclinical
Lead developer
THPharm
Modality
Small Molecules
Administration
Oral
01

Overview

Dapagliflozin + telmisartan is a fixed-dose combination therapy comprising dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and telmisartan, an angiotensin II receptor blocker (ARB). Dapagliflozin reduces blood glucose by inhibiting renal glucose reabsorption, leading to glycosuria, while telmisartan lowers blood pressure by selectively blocking angiotensin II type 1 (AT1) receptors to inhibit vasoconstriction and aldosterone secretion. This combination is considered for the management of patients who require glycemic control (type 2 diabetes mellitus) and antihypertensive therapy, with potential added benefits on cardiovascular and renal risk reduction. No fixed-brand name formulation is widely marketed as of September 2025, but both components are established as individual agents[2][5].

Brand names
Dapatelmi
Other names
telmisartan/dapagliflozin - THPharm
02

Targets

SGLT2 (Sodium-glucose cotransporter protein subunit 2)PPARG (Peroxisome proliferator-activated receptor gamma)AGTR1 (Angiotensin II Type-1 receptor)

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