dapsone + benzoyl peroxide

Dapsone + benzoyl peroxide is a topical combination therapy used primarily for the treatment of acne vulgaris. Dapsone is a sulfone antibiotic with both anti-inflammatory and antibacterial properties, acting by inhibiting dihydropteroate synthase and thus blocking folic acid synthesis in bacteria[1][5][6]. Benzoyl peroxide is an oxidizing agent with broad-spectrum antibacterial activity against Cutibacterium acnes (formerly Propionibacterium acnes) and also has mild keratolytic effects. When used together, these agents target multiple pathogenic factors in acne, including bacterial colonization and inflammation. However, concurrent application may cause temporary yellow or orange discoloration of the skin or facial hair[3][4][8]. This combination does not represent a single co-formulated product but rather refers to the sequential or concurrent use of both agents as part of an acne management regimen.

Brand names

Aczone + Benzac