DAPT + statin

DAPT + statin refers to the combination therapy of dual antiplatelet therapy (DAPT) and a statin, typically used in the management of acute ischemic stroke, transient ischemic attack (TIA), or atherosclerotic cardiovascular disease. DAPT usually consists of aspirin plus a P2Y12 inhibitor such as clopidogrel. Statins are lipid-lowering agents that inhibit HMG-CoA reductase, with atorvastatin or rosuvastatin commonly used at high intensity in this context. The combination aims to reduce recurrent vascular events by targeting both platelet aggregation (to prevent thrombosis) and cholesterol levels (to stabilize plaques and reduce inflammation). This regimen is supported by clinical trials for reducing early neurological deterioration, recurrent stroke, myocardial infarction, and all-cause mortality in patients with acute cerebrovascular events or high-risk profiles[1][5][6][10].

Other names

dual antiplatelet therapy plus statinDAPT and statinDAPT + high-intensity statin