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daptomycin + piperacillin-tazobactam
- Development stage
- Preclinical
- Lead developer
- Merck
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A combination antibiotic therapy consisting of daptomycin, a cyclic lipopeptide antibiotic, and piperacillin-tazobactam, a combination of a semisynthetic penicillin antibiotic and a β-lactamase inhibitor. This combination demonstrates synergistic activity against various bacterial pathogens, particularly methicillin-resistant Staphylococcus aureus (MRSA) and other resistant Gram-positive organisms.
02
Targets
KPC (Klebsiella pneumoniae carbapenemase)
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