darolutamide + radium-223

Darolutamide + radium-223 is a combination therapy under investigation for the treatment of metastatic castration-resistant prostate cancer (mCRPC) with bone metastases. Darolutamide is an orally administered second-generation androgen receptor inhibitor that blocks androgen receptor signaling, thereby inhibiting the growth of prostate cancer cells. Radium-223 dichloride is a targeted alpha-emitting radiopharmaceutical that mimics calcium and selectively binds to areas of increased bone turnover associated with bone metastases; it induces double-strand DNA breaks in adjacent tumor cells through alpha particle emission. Preclinical studies have demonstrated synergistic antitumor efficacy when these agents are combined, likely due to downregulation of DNA damage response pathways and enhanced suppression of tumor-induced pathological effects in bone[1][2]. Both drugs are approved individually for specific indications in prostate cancer.

Brand names

NubeqaXofigo

Other names

darolutamideradium-223 dichlorideradium223 dichlorideradium 223 dichloride