Drug intelligence / Profile preview

dasiglucagon + insulin aspart + insulin lispro

Development stage
Unknown
Lead developer
Zealand Pharma
Modality
Recombinant Proteins and Enzymes, Peptides
Administration
Subcutaneous
01

Overview

This is a combination of three distinct medications used in diabetes management:\n\n**Dasiglucagon**: A glucagon analog used to treat severe hypoglycemia in pediatric and adult patients with diabetes. It consists of 29 amino acids similar to endogenous glucagon but contains seven substituted amino acids for improved physical and chemical stability. Dasiglucagon acts to increase blood sugar levels and is available as a subcutaneous injection marketed as Zegalogue.\n\n**Insulin Aspart**: A rapid-acting insulin analog used to improve glycemic control in patients with diabetes. It has a more rapid onset of action compared to regular insulin, allowing for administration right at mealtime and providing better glycemic control while avoiding hypoglycemic episodes from errors in timing.\n\n**Insulin Lispro**: A rapid-acting insulin analog used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. It begins to exert its effects within 15 minutes of subcutaneous administration, with peak levels occurring 30 to 90 minutes after administration. Due to its duration of action of around 5 hours, it is considered \"bolus insulin\" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the pancreas after meals.

02

Targets

GCGR (Glucagon receptor)INSR (Insulin receptor)

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