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daunorubicin + cytarabine liposome (Jazz Pharmaceuticals plc, 041fa8)
- Development stage
- Phase 4
- Lead developer
- Jazz Pharmaceuticals
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
CPX-351 (Vyxeos) is a liposomal encapsulation of the anthracycline daunorubicin and the antimetabolite cytarabine in a fixed 1:5 molar ratio. This specific ratio has been shown in preclinical models to maximize synergistic antileukemic activity. The liposomal delivery system prolongs the half-life of the drugs in the plasma and preferentially accumulates in the bone marrow, where it is taken up by leukemia cells. It was developed by Celator Pharmaceuticals (now Jazz Pharmaceuticals) and is primarily indicated for the treatment of adults with newly-diagnosed therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-related changes (AML-MRC).
- Brand names
- Vyxeos
- Other names
- daunorubicin and cytarabine liposomeliposomal daunorubicin and cytarabine
02
Targets
DNATOP2A (DNA topoisomerase II)POLE (DNA polymerase epsilon)TOP2B (DNA topoisomerase II beta)
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