Drug intelligence / Profile preview

DC-806 + carbamazepine

Development stage
Unknown
Lead developer
Eli Lilly
Modality
Small Molecules
Administration
Oral
01

Overview

DC-806 + carbamazepine is a combination of DC-806, an investigational oral small molecule drug being developed for the treatment of plaque psoriasis, and carbamazepine, a well-established small molecule anticonvulsant used for epilepsy, trigeminal neuralgia, and bipolar disorder. DC-806 is currently in clinical trials and is being assessed for drug-drug interactions with carbamazepine. The primary mechanism of carbamazepine is inhibition of voltage-gated sodium channels, which reduces synaptic transmission and neuronal excitability. DC-806's mechanism has not been fully published but is being investigated for its immunomodulatory or anti-inflammatory potential in psoriasis.

Brand names
TegretolCarbatrolEpitolEquetroCarnexiv
Other names
CBZ5-Carbamoyl-5H-dibenz(b,f)azepineCarbamazepinaCarbamazepinum
02

Targets

IL-17A (Interleukin-17A)

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