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DENV-1-LVHC (strain 45AZ5)
- Development stage
- Phase 1
- Lead developer
- Upstate Medical University
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
DENV-1-LVHC (strain 45AZ5) is a live dengue virus serotype 1 challenge material developed for use in Controlled Human Infection Models (CHIM). Managed by the State University of New York (SUNY) Upstate Medical University, this specific strain is derived from a clinical isolate and is used to induce a predictable, uncomplicated dengue-like illness in healthy adult volunteers. This model serves as a critical tool for the clinical evaluation of dengue vaccine candidates and antiviral therapeutics, allowing researchers to measure protective efficacy in a small, controlled cohort before proceeding to large-scale field trials. The strain 45AZ5 was originally characterized by the Walter Reed Army Institute of Research (WRAIR) and is administered subcutaneously to mimic natural infection by mosquito bite.
- Other names
- Dengue-1 Virus-Live Virus Human ChallengeDengue1 Virus-Live Virus Human ChallengeDengue 1 Virus-Live Virus Human ChallengeDengue subtype 1 Challenge Virus strain 45AZ5
02
Targets
DC-SIGN (Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin)HS (Heparan sulfate)MRC1 (Mannose Receptor C-type 1)
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