Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
deoxycytidine + deoxythymidine
- Development stage
- Phase 2
- Lead developer
- UCB
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
deoxycytidine + deoxythymidine is an investigational combination therapy consisting of two small molecule nucleosides being developed by Suneet Agarwal at Boston Children's Hospital for the treatment of telomere biology disorders (TBDs). TBDs are rare, inherited conditions characterized by critically short telomeres, which lead to cellular senescence and organ failure, most commonly presenting as bone marrow failure. The therapy is based on research identifying thymidine nucleotide metabolism as a limiting factor in human telomere maintenance. By supplementing these nucleosides orally, the treatment aims to increase the available nucleotide pool to support telomere elongation and cellular replication. It is currently being evaluated in a Phase 1 clinical trial (NCT06817590) to assess safety and tolerability.
- Other names
- dC + dTNucleoside Therapy (dC + dT)
02
Targets
TK1 (Thymidine kinase 1)TK2 (Thymidine kinase 2)DNA
Beyond the preview
Go deeper on deoxycytidine + deoxythymidine.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on deoxycytidine + deoxythymidine.