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des-His1,Pro4,Glu9-glucagon
- Development stage
- Preclinical
- Lead developer
- Ulster University
- Modality
- Peptides
- Administration
- Intraperitoneal
01
Overview
des-His1,Pro4,Glu9-glucagon is a peptide-based glucagon receptor (GCGR) antagonist developed by researchers at the University of Ulster. It is a structurally modified analogue of native glucagon, designed to block glucagon-mediated signaling. In preclinical models of diabetes (such as streptozotocin-induced diabetic mice and high-fat-fed mice), chronic administration of des-His1,Pro4,Glu9-glucagon has been shown to delay the onset of hyperglycemia, improve oral glucose tolerance, enhance insulin sensitivity, and suppress hyperglucagonemia. It is primarily used as a research tool to study the therapeutic potential of glucagon receptor antagonism in diabetes and obesity.
- Other names
- [des-His1,Pro4,Glu9]glucagon[des-His1,Pro4,Glu9]glucagon amidedesHis1Pro4Glu9-glucagondesHis-1Pro4Glu9-glucagondesHis 1Pro4Glu9-glucagondesHis1Pro4Glu9glucagondesHis-1Pro4Glu9glucagondesHis 1Pro4Glu9glucagon
02
Targets
GCGR (Glucagon receptor)
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