Desloratadine + phenylephrine + ibuprofen

Desloratadine + phenylephrine + ibuprofen is a fixed-dose combination of three active pharmaceutical ingredients, each with distinct mechanisms of action. Desloratadine is a second-generation tricyclic antihistamine that selectively antagonizes peripheral histamine H1 receptors, reducing symptoms associated with allergic rhinitis such as sneezing, itching, and runny nose[1]. Phenylephrine is an alpha-1 adrenergic receptor agonist that acts as a decongestant by causing vasoconstriction in the nasal mucosa, thereby relieving nasal congestion[3]. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX-1 and COX-2), leading to reduced synthesis of prostaglandins involved in inflammation, pain, and fever[3]. This combination targets multiple symptoms commonly associated with upper respiratory tract infections such as the common cold or flu—including congestion, pain/fever, and allergic manifestations—and has been studied for this indication[2].

Brand names

Irlanda-1-AssociationIrlanda1-AssociationIrlanda 1-Association

Other names

Irlanda-1-AssociationIrlanda1-AssociationIrlanda 1-Association