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deslorelin + estradiol + medroxyprogesterone acetate + testosterone
- Development stage
- Unknown
- Lead developer
- Balance Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Intranasal, Transdermal
01
Overview
A combination therapy consisting of the gonadotropin-releasing hormone agonist (GnRHa) deslorelin with add-back hormones estradiol, medroxyprogesterone acetate, and testosterone. This combination has been studied for the treatment of endometriosis-related pelvic pain. The GnRHa component (deslorelin) suppresses ovarian production of hormones, while the add-back hormones help minimize hypoestrogenic side effects such as bone mineral density loss and hot flashes that would typically occur with GnRHa therapy alone.
02
Targets
GnRHR (Gonadotropin-releasing hormone receptor)ER (Estrogen receptor)AR (Adrenergic receptors)PR (Progesterone receptor)
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