devil's club root extract

Devil's club root extract is a botanical preparation derived from the root and inner bark of *Oplopanax horridus*, a spiny shrub native to the Pacific Northwest of North America. Traditionally used by indigenous peoples, it is employed for its potential **antimicrobial, anti-inflammatory, adaptogenic, hypoglycemic, and immunomodulatory properties**[1][2][4][5][7][8]. Key phytochemicals include **polyynes** (such as falcarindiol and oplopandiol), phenylpropanoids, lignan glycosides, and various terpenoids[5][7]. It has demonstrated *in vitro* and animal model activity against bacteria, fungi, and mycobacteria (such as the tuberculosis pathogen), as well as anticancer, immunostimulatory, and blood sugar-lowering effects[3][5][7][8][9]. Most common traditional indications include arthritis, diabetes, tuberculosis, digestive and respiratory ailments, and skin conditions[1][2][3][4][6][8]. There are no clinical trials or approvals for pharmaceutical use; evidence remains largely preclinical or ethnobotanical.

Brand names

Alaskan ginseng

Other names

devil's clubdevil’s club extractOplopanax horridus root extractEchinopanax horridusPanax horridumFatsia horridaBois PiquantDevil's RootGarrote del DiabloCukilanarpak