dexamethasone (Merck & Co.)

Dexamethasone is a synthetic, long-acting **glucocorticoid corticosteroid** that activates the glucocorticoid receptor to alter transcriptional programs controlling inflammation, immune activity, cell survival, and metabolism. In the Sun Yat-sen University Phase II GAD-M protocol, it was administered as one component of co-administered gemcitabine, pegaspargase, dexamethasone, and high-dose methotrexate for previously untreated extranodal NK/T-cell lymphoma; this entry denotes **dexamethasone itself**, not the four-drug GAD-M regimen. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01991158))

Brand names

Decadron

Other names

9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dionedexamethasone-Sun Yat-sen University-extranodal NK/T-cell lymphoma