dexamethasone + fludrocortisone

Dexamethasone + fludrocortisone is a combination of two synthetic corticosteroids. Dexamethasone is a potent glucocorticoid with strong anti-inflammatory and immunosuppressive properties, while fludrocortisone is primarily a mineralocorticoid used for its salt-retaining effects. This combination has been investigated for use in severe inflammatory conditions such as sepsis and septic shock, where corticosteroid therapy may reduce mortality and improve clinical outcomes by modulating the body's response to systemic infection. Dexamethasone acts mainly through the glucocorticoid receptor to suppress pro-inflammatory gene expression, whereas fludrocortisone acts on the mineralocorticoid receptor to promote sodium retention and maintain vascular tone[1][3][4]. The combination aims to leverage both anti-inflammatory (dexamethasone) and hemodynamic-stabilizing (fludrocortisone) effects.