dexamethasone + lidocaine

Dexamethasone + lidocaine is a combination drug consisting of dexamethasone, a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressant properties, and lidocaine, an amide-type local anesthetic that provides rapid pain relief by blocking sodium channels in neuronal membranes. This combination is used to provide both immediate analgesia (from lidocaine) and longer-term anti-inflammatory effects (from dexamethasone). It has been studied for use in perioperative pain management (e.g., reducing injection pain during propofol administration), oral inflammatory conditions such as mucositis or lichen planus, and as an adjuvant in regional anesthesia[2][5][7]. Dexamethasone acts primarily via activation of the glucocorticoid receptor to inhibit pro-inflammatory gene expression and reduce leukocyte migration; lidocaine blocks voltage-gated sodium channels to prevent nerve impulse conduction[9][10].

Brand names

LIDOCIDEX-IReadySharp Anesthetics Plus Dexamethasone

Other names

dexamethasone sodium phosphate/lidocaine HCldexamethasone + lidocaine oral rinse