dexamethasone + methylprednisolone + bupivacaine

This drug is an intra-articular injectable combination consisting of two corticosteroids, dexamethasone (8mg) and methylprednisolone (80mg), and a local anesthetic, bupivacaine (5ml 0.25%). It is utilized as a standard-of-care control treatment for the non-operative management of moderate to severe knee osteoarthritis in clinical trials conducted by the Cappagh National Orthopaedic Hospital. Dexamethasone and methylprednisolone act as potent anti-inflammatory agents by activating glucocorticoid receptors, while bupivacaine provides immediate pain relief by blocking voltage-gated sodium channels. This specific formulation is evaluated against novel treatments like polyacrylamide hydrogels to determine comparative efficacy in delaying the need for surgical intervention.

Other names

Steroid Drugsteroid and local anaestheticsteroid-Cappagh National Orthopaedic Hospital-osteoarthritis