dexamethasone + ondansetron + droperidol

This is a combination of three pharmaceutical agents—dexamethasone, ondansetron, and droperidol—used primarily for the prevention and treatment of postoperative nausea and vomiting (PONV). Dexamethasone is a synthetic glucocorticoid corticosteroid with anti-inflammatory and antiemetic properties. Ondansetron is a selective serotonin 5-HT3 receptor antagonist that blocks serotonin both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. Droperidol is a butyrophenone derivative that acts as an antagonist at dopamine D2 receptors in the central nervous system, providing antiemetic effects. The triple combination has been shown to have additive or synergistic efficacy in reducing PONV compared to dual or monotherapy regimens[1][2][3][5]. Each component targets different emetogenic pathways, resulting in enhanced prophylactic effect.