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dexamethasone + povidone-iodine
- Development stage
- Phase 3
- Lead developer
- Takeda
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Ophthalmic
01
Overview
A fixed-dose combination of dexamethasone, a synthetic glucocorticoid corticosteroid, and povidone-iodine, an iodophore antiseptic. This ophthalmic suspension was developed for the treatment of infectious conjunctivitis, particularly adenoviral conjunctivitis. Dexamethasone acts as a potent anti-inflammatory agent by agonizing the glucocorticoid receptor and suppressing inflammatory mediators. Povidone-iodine provides broad-spectrum antimicrobial activity by releasing free iodine that disrupts microbial proteins and nucleic acids. The combination aims to reduce both inflammation and viral load in ocular infections. Clinical trials demonstrated improved clinical resolution rates compared to monotherapy or vehicle; however, development was discontinued after phase III trials[1][3][5].
- Other names
- dexamethasone/povidone iodine ophthalmic suspensionpovidone iodine/dexamethasone ophthalmic suspension
02
Targets
GR (Glucocorticoid receptor)
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