dexamethasone + prednisolone

Dexamethasone + prednisolone is a combination of two synthetic glucocorticoid corticosteroids. Both drugs act as anti-inflammatory and immunosuppressive agents by binding to the glucocorticoid receptor, modulating gene expression, and suppressing pro-inflammatory cytokines. This combination has been studied for its enhanced antileukemic activity in pediatric acute lymphoblastic leukemia (ALL), where low-dose dexamethasone added to prednisolone can potentiate cytotoxic effects on leukemic cells compared to either agent alone[1][9]. Both drugs are also used in various inflammatory, allergic, autoimmune, and oncologic conditions due to their ability to reduce inflammation and immune responses[3][5][7]. The rationale for combining them is based on their differing pharmacokinetics and potencies—dexamethasone is more potent with a longer duration of action than prednisolone—and evidence suggests that the combination may overcome resistance seen with single-agent therapy in some patients[1][9].

Other names

dexamethasone-King Fahd General Hospital-postoperative pain-postoperative nausea and vomitingIV dexamethasone and oral prednisolone regimenSteroids for Post-tonsillectomy Morbidities