Drug intelligence / Profile preview

dexamethasone + Ringer's solution

Development stage
Preclinical
Lead developer
Shiraz University of Medical Sciences
Modality
Small Molecules
Administration
Intraarticular
01

Overview

Dexamethasone is a synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive properties. In the clinical study conducted by Shiraz University of Medical Sciences, it is administered in combination with Ringer's solution during temporomandibular joint (TMJ) arthrocentesis. This procedure involves the lavage of the joint space to remove inflammatory mediators and release the articular disc. The addition of dexamethasone aims to provide sustained anti-inflammatory action within the joint to improve clinical outcomes such as pain reduction and increased range of motion in patients with internal derangement of the TMJ.

Other names
dexamethasone sodium phosphatecorticosteroid in TMJ arthrocentesis
02

Targets

GR (Glucocorticoid receptor)

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