Drug intelligence / Profile preview

dexamethasone + salbutamol

Development stage
Phase 1
Lead developer
GSK
Modality
Small Molecules
Administration
Oral, Inhalation, Intramuscular
01

Overview

**dexamethasone + salbutamol** is a combination therapy consisting of two drugs: dexamethasone, a synthetic corticosteroid, and salbutamol (also known as albuterol), a selective beta-2 adrenergic receptor agonist. Dexamethasone acts by suppressing inflammation and immune responses, stabilizing cell membranes, and reducing airway edema. Salbutamol relaxes bronchial smooth muscle through stimulation of beta-2 receptors, leading to bronchodilation and rapid relief of bronchospasm. This combination is primarily used in the treatment of acute wheezing, asthma exacerbations, and lower respiratory conditions in infants and children where both airway inflammation and bronchospasm are contributing factors. Evidence suggests that the combination may offer improved efficacy due to possible synergistic effects: corticosteroids may potentiate beta-2 receptor responsiveness, resulting in more rapid and marked clinical improvement in acute episodes compared to monotherapy with either agent[1][3][9].

Other names
albuterol + dexamethasone
02

Targets

ADRB2 (β2)GR (Glucocorticoid receptor)

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