Drug intelligence / Profile preview

dexamethasone + timolol

Development stage
Unknown
Lead developer
Tufts University School of Medicine
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

**dexamethasone + timolol** is a combination of two well-established drugs used in ophthalmology: dexamethasone, a synthetic glucocorticoid with anti-inflammatory and immunosuppressive effects, and timolol, a nonselective beta-adrenergic antagonist. While each agent has its own indications and mechanisms—dexamethasone is used for reducing inflammation and timolol for lowering intraocular pressure (IOP) in ocular hypertension and glaucoma—their combination is not a standard, commercially available fixed-dose product. However, there is clinical evidence that pretreatment with dexamethasone can enhance the acute ocular hypotensive effect of timolol, suggesting a potential synergistic effect in lowering IOP, particularly in the context of ocular hypertension and glaucoma[1].

Other names
dexamethasone-timololdexamethasone timolol
02

Targets

GR (Glucocorticoid receptor)ADRB2 (β2)ADRB1 (β1)

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