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dexamethasone palmitate + ropivacaine
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Infiltration
01
Overview
This is a combination of dexamethasone palmitate (D-PAL/DXP), a liposomal formulation of dexamethasone, with ropivacaine, a local anesthetic. Dexamethasone palmitate is a pro-drug that incorporates dexamethasone into lipid microspheres, providing 5-6 times greater anti-inflammatory activity and fewer systemic side effects than free dexamethasone. When combined with ropivacaine, this formulation is being investigated for pre-incisional infiltration in various surgical procedures to reduce postoperative pain. The combination has shown promise in clinical trials for post-craniotomy pain, spine surgery pain, and thoracic herpes zoster-associated pain.
- Other names
- D-PAL + ropivacaineDXP + ropivacaine
02
Targets
GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)
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