Drug intelligence / Profile preview

dexamethasone sodium phosphate + bupivacaine hydrochloride + isopropyl alcohol + povidone-iodine

Development stage
Unknown
Lead developer
Asclemed USA
Modality
Small Molecules
Administration
Topical, Intramuscular, Parenteral
01

Overview

**Dexamethasone sodium phosphate + bupivacaine hydrochloride + isopropyl alcohol + povidone-iodine** is a multi-component pharmaceutical kit marketed as **Mardex 25 Kit** by **Asclemed USA**. The kit combines dexamethasone sodium phosphate, a glucocorticoid receptor agonist corticosteroid that suppresses inflammatory signaling, with bupivacaine hydrochloride, an amide local anesthetic that blocks voltage-gated sodium channels to inhibit nerve impulse conduction and provide local or regional anesthesia and analgesia; isopropyl alcohol and povidone-iodine are included as topical antiseptic skin-preparation components for the procedure. Public labeling describes the kit as intended for anesthesia and analgesia-related procedural use and shows a package containing bupivacaine HCl 0.25% single-dose vial, dexamethasone sodium phosphate injection 10 mg/mL, povidone-iodine swabsticks, and 70% isopropyl alcohol prep pads. The product is listed in DailyMed as an unapproved drug product whose labeling has not been approved by the FDA.

Brand names
Mardex 25 KitMardex25 KitMardex-25 KitMardex-25Mardex25Mardex 25
Other names
dexamethasone sodium phosphate + bupivacaine hydrochloride + isopropyl alcohol + povidone-iodinedexamethasone sodium phosphate + bupivacaine hydrochloride + povidone-iodine
02

Targets

NaV (Voltage-gated sodium channels)GR (Glucocorticoid receptor)

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