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dexmedetomidine + bupivacaine + fentanyl
- Development stage
- Unknown
- Lead developer
- King Abdulaziz Medical City
- Modality
- Small Molecules
- Administration
- Intrathecal, Intravenous
01
Overview
This drug entry refers to a combination regimen consisting of the alpha-2 adrenergic agonist dexmedetomidine, the local anesthetic bupivacaine, and the opioid analgesic fentanyl. This specific combination is being evaluated in a Phase 4 clinical trial sponsored by King Abdulaziz Medical City to determine the effects of dexmedetomidine as an adjuvant to spinal anesthesia in patients undergoing orthopedic surgery. The study compares two interventional protocols: one where dexmedetomidine is administered intrathecally alongside bupivacaine and fentanyl, and another where it is administered intravenously following a spinal block of bupivacaine and fentanyl. The primary goal is to assess the prolongation of spinal anesthesia and the time of motor block regression.
- Brand names
- DemexaBucaineMartindale pharma Fentanyl
- Other names
- Interventional-King Abdulaziz Medical City-Orthopedic surgery
02
Targets
ADRA2A (α2A)MOR (Mu opioid receptor)NaV (Voltage-gated sodium channels)
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