Drug intelligence / Profile preview

dexmedetomidine + glycopyrrolate + isoproterenol

Development stage
Unknown
Modality
Small Molecules
Administration
Intravenous, Inhalation, Sublingual, Rectal
01

Overview

The combination of dexmedetomidine, glycopyrrolate, and isoproterenol is not specifically described in the provided search results. Isoproterenol (also known as isoprenaline) is a sympathomimetic medication primarily used for treating bradycardia, heart block, and cardiac arrest. It works by stimulating β-adrenergic receptors (both β1 and β2), which increases heart rate and the force of heart contractions. Common side effects of isoproterenol include: headache, dizziness, nervousness, nausea, blurred vision, tremors, sweating, flushing, tachycardia, palpitations, and anxiety. More serious side effects may include: chest pain, severe arrhythmias, hypertension or hypotension, shortness of breath, and pulmonary edema. Isoproterenol is typically administered intravenously for bradycardia or heart block, and sometimes via inhalation for respiratory conditions. In the past, it was also administered under the tongue or into the rectum. Dexmedetomidine is an alpha-2 adrenergic receptor agonist used for sedation in intensive care settings and during procedures. Glycopyrrolate is an anticholinergic medication often used to reduce secretions and block certain vagal effects during anesthesia.

02

Targets

CHRM2 (M2)ADRA2A (α2A)ADRB2 (β2)ADRB1 (β1)

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