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dexmedetomidine + ropivacaine + ketorolac
- Development stage
- Phase 1
- Lead developer
- Massachusetts General Hospital
- Modality
- Small Molecules
- Administration
- Local Infiltration
01
Overview
This multimodal analgesic combination consists of dexmedetomidine, ropivacaine, and ketorolac, developed by Massachusetts General Hospital for the management of postoperative pain. It is administered via a rectus sheath block to provide localized pain relief and reduce the consumption of systemic opioids following surgery. Ropivacaine acts as a long-acting local anesthetic by blocking sodium channels, ketorolac provides anti-inflammatory and analgesic effects through the inhibition of cyclooxygenase enzymes, and dexmedetomidine, an alpha-2 adrenergic agonist, serves as an adjuvant to prolong the duration of the block and enhance the sedative/analgesic effect.
- Other names
- Multimodal analgesia
02
Targets
ADRA2A (α2A)ADRA2B (α2B)ADRA2C (α2C)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)
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